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DNMT3a-triggered downregulation of K(2p)1.1 gene in primary sensory neurons contributes to paclitaxel-induced neuropathic pain

Antineoplastic drugs induce dramatic transcriptional changes in dorsal root ganglion (DRG) neurons, which may contribute to chemotherapy-induced neuropathic pain. K(2p)1.1 controls neuronal excitability by setting the resting membrane potential. Here, we report that systemic injection of the chemoth...

詳細記述

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書誌詳細
出版年:Int J Cancer
主要な著者: Mao, Qingxiang, Wu, Shaogen, Gu, Xiyao, Du, Shibin, Mo, Kai, Sun, Linlin, Cao, Jing, Bekker, Alex, Chen, Liyong, Tao, Yuan-Xiang
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6660426/
https://ncbi.nlm.nih.gov/pubmed/30684388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.32155
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