Global view of the RAF-MEK-ERK module and its immediate downstream effectors

Small molecule inhibitors of BRAF and MEK have proven effective at inhibiting tumor growth in melanoma patients, however this efficacy is limited due to the almost universal development of drug resistance. To provide advanced insight into the signaling responses that occur following kinase inhibitio...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Santini, Cristina C., Longden, James, Schoof, Erwin M., Simpson, Craig D., Jeschke, Grace R., Creixell, Pau, Kim, Jinho, Wu, Xuewei, Turk, Benjamin E., Rosen, Neal, Poulikakos, Poulikos I., Linding, Rune
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2019
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6659682/
https://ncbi.nlm.nih.gov/pubmed/31350469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47245-x
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