Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis

DiGeorge syndrome critical region 8 (DGCR8) is a critical component of the canonical microprocessor complex for microRNA biogenesis. However, the non-canonical functions of DGCR8 have not been studied. Here, we demonstrate that DGCR8 plays an important role in maintaining heterochromatin organizatio...

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Vydáno v:Nat Commun
Hlavní autoři: Deng, Liping, Ren, Ruotong, Liu, Zunpeng, Song, Moshi, Li, Jingyi, Wu, Zeming, Ren, Xiaoqing, Fu, Lina, Li, Wei, Zhang, Weiqi, Guillen, Pedro, Izpisua Belmonte, Juan Carlos, Chan, Piu, Qu, Jing, Liu, Guang-Hui
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6659673/
https://ncbi.nlm.nih.gov/pubmed/31350386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10831-8
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