ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin

Zinc finger protein with KRAB and SCAN domains 3 (ZKSCAN3) has long been known as a master transcriptional repressor of autophagy. Here, we identify a novel role for ZKSCAN3 in alleviating senescence that is independent of its autophagy-related activity. Downregulation of ZKSCAN3 is observed in aged...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Hu, Huifang, Ji, Qianzhao, Song, Moshi, Ren, Jie, Liu, Zunpeng, Wang, Zehua, Liu, Xiaoqian, Yan, Kaowen, Hu, Jianli, Jing, Yaobin, Wang, Si, Zhang, Weiqi, Liu, Guang-Hui, Qu, Jing
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293006/
https://ncbi.nlm.nih.gov/pubmed/32427330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa425
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