NPM1c alters FLT3-D835Y localization and signaling in acute myeloid leukemia

Activating mutations in FMS-like tyrosine kinase receptor-3 (FLT3) and Nucleophosmin-1 (NPM1) are most frequent alterations in acute myeloid leukemia (AML), and are often coincidental. The mutational status of NPM1 has strong prognostic relevance to patients with point mutations of the FLT3 tyrosine...

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Bibliografski detalji
Izdano u:Blood
Glavni autori: Rudorf, Alina, Müller, Tony Andreas, Klingeberg, Cathrin, Kreutmair, Stefanie, Poggio, Teresa, Gorantla, Sivahari Prasad, Rückert, Tamina, Schmitt-Graeff, Annette, Gengenbacher, Anina, Paschka, Peter, Baldus, Claudia, Zeiser, Robert, Vassiliou, George S., Bradley, Allan, Duyster, Justus, Illert, Anna Lena
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2019
Teme:
Myeloid Neoplasia
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6659255/
https://ncbi.nlm.nih.gov/pubmed/31186273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2018883140
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