NPM1c alters FLT3-D835Y localization and signaling in acute myeloid leukemia

Activating mutations in FMS-like tyrosine kinase receptor-3 (FLT3) and Nucleophosmin-1 (NPM1) are most frequent alterations in acute myeloid leukemia (AML), and are often coincidental. The mutational status of NPM1 has strong prognostic relevance to patients with point mutations of the FLT3 tyrosine...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Rudorf, Alina, Müller, Tony Andreas, Klingeberg, Cathrin, Kreutmair, Stefanie, Poggio, Teresa, Gorantla, Sivahari Prasad, Rückert, Tamina, Schmitt-Graeff, Annette, Gengenbacher, Anina, Paschka, Peter, Baldus, Claudia, Zeiser, Robert, Vassiliou, George S., Bradley, Allan, Duyster, Justus, Illert, Anna Lena
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6659255/
https://ncbi.nlm.nih.gov/pubmed/31186273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2018883140
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