NPM1c alters FLT3-D835Y localization and signaling in acute myeloid leukemia

Activating mutations in FMS-like tyrosine kinase receptor-3 (FLT3) and Nucleophosmin-1 (NPM1) are most frequent alterations in acute myeloid leukemia (AML), and are often coincidental. The mutational status of NPM1 has strong prognostic relevance to patients with point mutations of the FLT3 tyrosine...

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Detalles Bibliográficos
Publicado en:Blood
Main Authors: Rudorf, Alina, Müller, Tony Andreas, Klingeberg, Cathrin, Kreutmair, Stefanie, Poggio, Teresa, Gorantla, Sivahari Prasad, Rückert, Tamina, Schmitt-Graeff, Annette, Gengenbacher, Anina, Paschka, Peter, Baldus, Claudia, Zeiser, Robert, Vassiliou, George S., Bradley, Allan, Duyster, Justus, Illert, Anna Lena
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2019
Assuntos:
Myeloid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6659255/
https://ncbi.nlm.nih.gov/pubmed/31186273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2018883140
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