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Impact of Selective CD28 Blockade on Virus-Specific Immunity to a Murine EBV Homolog
CTLA-4Ig (belatacept) blocks the CD80/CD86 ligands for both CD28 and CTLA-4; thus, in addition to the intended effect of blocking CD28-mediated costimulation, belatacept also has the unintended effect of blocking CTLA-4-mediated coinhibition. Recently, anti-CD28 domain antibodies (dAb) that selectiv...
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| Publicado no: | Am J Transplant |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6658342/ https://ncbi.nlm.nih.gov/pubmed/30801917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.15321 |
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