Targeting the CBM complex causes Treg cells to prime tumors for immune checkpoint therapy

Solid tumors are infiltrated by effector T cells (Teff) with the potential to control or reject them, as well as by regulatory T cells (Treg) that restrict the function of Teff and thereby promote tumor growth.(1) The anti-tumor activity of Teff can be therapeutically unleashed and is now being expl...

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Pubblicato in:Nature
Autori principali: Pilato, Mauro Di, Kim, Edward Y., Cadilha, Bruno L., Pruessmann, Jasper N., Nasrallah, Mazen N., Seruggia, Davide, Usmani, Shariq M., Misale, Sandra, Zappulli, Valentina, Carrizosa, Esteban, Mani, Vinidhra, Ligorio, Matteo, Warner, Ross D., Medoff, Benjamin D., Marangoni, Francesco, Villani, Alexandra-Chloe, Mempel, Thorsten R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6656391/
https://ncbi.nlm.nih.gov/pubmed/31092922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1215-2
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