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Tumor tolerance-promoting function of regulatory T cells is optimized by CD28, but strictly dependent on calcineurin
Regulatory T cells (Treg) restrain immune responses against malignant tumors, but their global depletion in cancer patients will likely be limited by systemic autoimmune toxicity. Instead, approaches to ‘tune’ their activities may allow for preferential targeting of tumor-reactive Treg. While antige...
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| Udgivet i: | J Immunol |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5940497/ https://ncbi.nlm.nih.gov/pubmed/29661826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701220 |
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