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An obligate cell-intrinsic function for CD28 in Tregs
Tregs expressing the transcription factor FOXP3 are critical for immune homeostasis. The costimulatory molecule CD28 is required for optimal activation and function of naive T cells; however, its role in Treg function has been difficult to dissect, as CD28 is required for thymic Treg development, an...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3561819/ https://ncbi.nlm.nih.gov/pubmed/23281398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65013 |
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