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An obligate cell-intrinsic function for CD28 in Tregs
Tregs expressing the transcription factor FOXP3 are critical for immune homeostasis. The costimulatory molecule CD28 is required for optimal activation and function of naive T cells; however, its role in Treg function has been difficult to dissect, as CD28 is required for thymic Treg development, an...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3561819/ https://ncbi.nlm.nih.gov/pubmed/23281398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65013 |
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