Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE

N-Acyl sulfamoyladenosines (acyl-AMS) have been used extensively to inhibit adenylate-forming enzymes that are involved in a wide range of biological processes. These acyl-AMS inhibitors are nonhydrolyzable mimics of the cognate acyl adenylate intermediates that are bound tightly by adenylate-formin...

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Veröffentlicht in:Biochemistry
Hauptverfasser: Evans, Christopher E., Si, Yuanyuan, Matarlo, Joe S., Yin, Yue, French, Jarrod B., Tonge, Peter J., Tan, Derek S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6653581/
https://ncbi.nlm.nih.gov/pubmed/30912442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00003
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