Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration

Background: Parkinson’s disease (PD) is one of the most common neurodegenerative disorders involving devastating loss of dopaminergic neurons in the substantia nigra. Early steps in PD pathogenesis include mitochondrial dysfunction, and mutations in mitochondrial genes have been linked to familial f...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Hartman, Jessica H., Gonzalez-Hunt, Claudia, Hall, Samantha M., Ryde, Ian T., Caldwell, Kim A., Caldwell, Guy A., Meyer, Joel N.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6651461/
https://ncbi.nlm.nih.gov/pubmed/31261893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20133202
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