Integrated Approach Reveals Role of Mitochondrial Germ-Line Mutation F18L in Respiratory Chain, Oxidative Alterations, Drug Sensitivity, and Patient Prognosis in Glioblastoma

Glioblastoma is the most common and malignant primary brain tumour in adults, with a dismal prognosis. This is partly due to considerable inter- and intra-tumour heterogeneity. Changes in the cellular energy-producing mitochondrial respiratory chain complex (MRC) activities are a hallmark of gliobla...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Keatley, Kathleen, Stromei-Cleroux, Samuel, Wiltshire, Tammy, Rajala, Nina, Burton, Gary, Holt, William V., Littlewood, D. Timothy J., Briscoe, Andrew G., Jung, Josephine, Ashkan, Keyoumars, Heales, Simon J., Pilkington, Geoffrey J., Meunier, Brigitte, McGeehan, John E., Hargreaves, Iain P., McGeehan, Rhiannon E.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6651022/
https://ncbi.nlm.nih.gov/pubmed/31323957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20133364
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