Identification and functional prediction of mitochondrial complex III and IV mutations associated with glioblastoma

BACKGROUND: Glioblastoma (GBM) is the most common primary brain tumor in adults, with a dismal prognosis. Treatment is hampered by GBM's unique biology, including differential cell response to therapy. Although several mitochondrial abnormalities have been identified, how mitochondrial DNA (mtD...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Lloyd, Rhiannon E., Keatley, Kathleen, Littlewood, D. Timothy J., Meunier, Brigitte, Holt, William V., An, Qian, Higgins, Samantha C., Polyzoidis, Stavros, Stephenson, Katie F., Ashkan, Keyoumars, Fillmore, Helen L., Pilkington, Geoffrey J., McGeehan, John E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474231/
https://ncbi.nlm.nih.gov/pubmed/25731774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov020
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