Identification and functional prediction of mitochondrial complex III and IV mutations associated with glioblastoma

BACKGROUND: Glioblastoma (GBM) is the most common primary brain tumor in adults, with a dismal prognosis. Treatment is hampered by GBM's unique biology, including differential cell response to therapy. Although several mitochondrial abnormalities have been identified, how mitochondrial DNA (mtD...

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Foilsithe in:Neuro Oncol
Main Authors: Lloyd, Rhiannon E., Keatley, Kathleen, Littlewood, D. Timothy J., Meunier, Brigitte, Holt, William V., An, Qian, Higgins, Samantha C., Polyzoidis, Stavros, Stephenson, Katie F., Ashkan, Keyoumars, Fillmore, Helen L., Pilkington, Geoffrey J., McGeehan, John E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2015
Ábhair:
Basic and Translational Investigations
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474231/
https://ncbi.nlm.nih.gov/pubmed/25731774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov020
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