Identification and functional prediction of mitochondrial complex III and IV mutations associated with glioblastoma

BACKGROUND: Glioblastoma (GBM) is the most common primary brain tumor in adults, with a dismal prognosis. Treatment is hampered by GBM's unique biology, including differential cell response to therapy. Although several mitochondrial abnormalities have been identified, how mitochondrial DNA (mtD...

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Udgivet i:Neuro Oncol
Main Authors: Lloyd, Rhiannon E., Keatley, Kathleen, Littlewood, D. Timothy J., Meunier, Brigitte, Holt, William V., An, Qian, Higgins, Samantha C., Polyzoidis, Stavros, Stephenson, Katie F., Ashkan, Keyoumars, Fillmore, Helen L., Pilkington, Geoffrey J., McGeehan, John E.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Basic and Translational Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474231/
https://ncbi.nlm.nih.gov/pubmed/25731774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov020
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