Biochemical Assessment and Monitoring of Mitochondrial Disease

Por Hargreaves, Iain P.
Publicado no J Clin Med (2018)

Assessment of Mitochondrial Dysfunction in Experimental Autoimmune Encephalomyelitis (EAE) Models of Multiple Sclerosis

Por Ng, Xiulin, Sadeghian, Mona, Heales, Simon, Hargreaves, Iain P.
Publicado no Int J Mol Sci (2019)

Biochemical Diagnosis of Coenzyme Q(10) Deficiency

Por Yubero, Delia, Montero, Raquel, Artuch, Rafael, Land, John M., Heales, Simon J.R., Hargreaves, Iain P.
Publicado em 2014

Evidence of Oxidative Stress and Secondary Mitochondrial Dysfunction in Metabolic and Non-Metabolic Disorders

Por Stepien, Karolina M., Heaton, Robert, Rankin, Scott, Murphy, Alex, Bentley, James, Sexton, Darren, Hargreaves, Iain P.
Publicado no J Clin Med (2017)

The Effect of Organophosphate Exposure on Neuronal Cell Coenzyme Q(10) Status

Por Turton, Nadia, Heaton, Robert A., Ismail, Fahima, Roberts, Sioned, Nelder, Sian, Phillips, Sue, Hargreaves, Iain P.
Publicado no Neurochem Res (2020)

The Effect of Methylmalonic Acid Treatment on Human Neuronal Cell Coenzyme Q(10) Status and Mitochondrial Function

Por Proctor, Emma C., Turton, Nadia, Boan, Elle Jo, Bennett, Emily, Philips, Suzannah, Heaton, Robert A., Hargreaves, Iain P.
Publicado no Int J Mol Sci (2020)

Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats

Por Tarry-Adkins, Jane L., Fernandez-Twinn, Denise S., Chen, Jian Hua, Hargreaves, Iain P., Neergheen, Viruna, Aiken, Catherine E., Ozanne, Susan E.
Publicado no Dis Model Mech (2016)

Nutritional programming of coenzyme Q: potential for prevention and intervention?

Por Tarry-Adkins, Jane L., Fernandez-Twinn, Denise S., Chen, Jian-Hua, Hargreaves, Iain P., Martin-Gronert, Malgorzata S., McConnell, Josie M., Ozanne, Susan E.
Publicado no FASEB J (2014)

CoQ(10) Deficient Endothelial Cell Culture Model for the Investigation of CoQ(10) Blood–Brain Barrier Transport

Por Wainwright, Luke, Hargreaves, Iain P., Georgian, Ana R., Turner, Charles, Dalton, R. Neil, Abbott, N. Joan, Heales, Simon J. R., Preston, Jane E.
Publicado no J Clin Med (2020)

Coenzyme Q(10) Prevents Insulin Signaling Dysregulation and Inflammation Prior to Development of Insulin Resistance in Male Offspring of a Rat Model of Poor Maternal Nutrition and...

Por Tarry-Adkins, Jane L., Fernandez-Twinn, Denise S., Madsen, Ralitsa, Chen, Jian-Hua, Carpenter, Asha, Hargreaves, Iain P., McConnell, Josie M., Ozanne, Susan E.
Publicado no Endocrinology (2015)

Altered skeletal muscle insulin signaling and mitochondrial complex II-III linked activity in adult offspring of obese mice

Por Shelley, Piran, Martin-Gronert, Malgorzata S., Rowlerson, Anthea, Poston, Lucilla, Heales, S. J. R., Hargreaves, Iain P., McConnell, Josie M., Ozanne, Susan E., Fernandez-Twinn, Denise S.
Publicado em 2009

OP55 BIOCHEMICAL ANALYSIS COMBINED WITH 3D STRUCTURAL PROTEIN MODELLING IDENTIFIES THE ROLE OF SPECIFIC MITOCHONDRIAL MUTATIONS IN GBM

Por Keatley, Kathleen, Polyzoidis, Stavros, Ashkan, Keyoumars, Heales, Simon J., Fillmore, Helen L., Hargreaves, Iain P., McGeehan, John E., Lloyd, Rhiannon E., Pilkington, Geoffrey J.
Publicado no Neuro Oncol (2015)

Coenzyme Q(10) prevents hepatic fibrosis, inflammation, and oxidative stress in a male rat model of poor maternal nutrition and accelerated postnatal growth(1)

Por Tarry-Adkins, Jane L, Fernandez-Twinn, Denise S, Hargreaves, Iain P, Neergheen, Viruna, Aiken, Catherine E, Martin-Gronert, Malgorzata S, McConnell, Josie M, Ozanne, Susan E
Publicado no Am J Clin Nutr (2016)

Coenzyme Q(10) prevents accelerated cardiac aging in a rat model of poor maternal nutrition and accelerated postnatal growth()

Por Tarry-Adkins, Jane L., Blackmore, Heather L., Martin-Gronert, Malgorzata S., Fernandez-Twinn, Denise S., McConnell, Josie M., Hargreaves, Iain P., Giussani, Dino A., Ozanne, Susan E.
Publicado em 2013

Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease

Por Osellame, Laura D., Rahim, Ahad A., Hargreaves, Iain P., Gegg, Matthew E., Richard-Londt, Angela, Brandner, Sebastian, Waddington, Simon N., Schapira, Anthony H.V., Duchen, Michael R.
Publicado em 2013

Maternal but not fetoplacental health can be improved by metformin in a murine diet-induced model of maternal obesity and glucose intolerance

Por Hufnagel, Antonia, Fernandez-Twinn, Denise S, Blackmore, Heather L, Ashmore, Thomas J, Heaton, Robert A, Jenkins, Benjamin, Koulman, Albert, Hargreaves, Iain P, Aiken, Catherine E, Ozanne, Susan E
Publicado no J Physiol (2022)

Using a quantitative quadruple immunofluorescent assay to diagnose isolated mitochondrial Complex I deficiency

Por Ahmed, Syeda T., Alston, Charlotte L., Hopton, Sila, He, Langping, Hargreaves, Iain P., Falkous, Gavin, Oláhová, Monika, McFarland, Robert, Turnbull, Doug M., Rocha, Mariana C., Taylor, Robert W.
Publicado no Sci Rep (2017)

Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease()

Por Dunn, Laura, Allen, George FG., Mamais, Adamantios, Ling, Helen, Li, Abi, Duberley, Kate E., Hargreaves, Iain P., Pope, Simon, Holton, Janice L., Lees, Andrew, Heales, Simon J., Bandopadhyay, Rina
Publicado em 2014

Multisystem mitochondrial disease caused by a rare m.10038G>A mitochondrial tRNA(Gly) (MT-TG) variant

Por Poole, Olivia V., Horga, Alejandro, Hardy, Steven A., Bugiardini, Enrico, Woodward, Cathy E., Hargreaves, Iain P., Merve, Ashirwad, Quinlivan, Rosaline, Taylor, Robert W., Hanna, Michael G., Pitceathly, Robert D.S.
Publicado no Neurol Genet (2020)

Autosomal-recessive cerebellar ataxia caused by a novel ADCK3 mutation that elongates the protein: clinical, genetic and biochemical characterisation

Por Liu, Yo-Tsen, Hersheson, Joshua, Plagnol, Vincent, Fawcett, Katherine, Duberley, Kate E C, Preza, Elisavet, Hargreaves, Iain P, Chalasani, Annapurna, Laurá, Matilde, Wood, Nick W, Reilly, Mary M, Houlden, Henry
Publicado em 2014