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Pioglitazone Reduces β Amyloid Levels via Inhibition of PPARγ Phosphorylation in a Neuronal Model of Alzheimer’s Disease

It has been demonstrated that peroxisome proliferator-activated receptor γ (PPARγ) can regulate the transcription of its target gene, insulin-degrading enzyme (IDE), and thus enhance the expression of the IDE protein. The protein can degrade β amyloid (Aβ), a core pathological product of Alzheimer’s...

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Bibliografiske detaljer
Udgivet i:Front Aging Neurosci
Main Authors: Quan, Qiankun, Qian, Yihua, Li, Xi, Li, Ming
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6650543/
https://ncbi.nlm.nih.gov/pubmed/31379559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2019.00178
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