PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer’s disease model

Current therapies for Alzheimer’s disease (AD) are symptomatic and do not target the underlying Aβ pathology and other important hallmarks including neuronal loss. PPARγ-coactivator-1α (PGC-1α) is a cofactor for transcription factors including the peroxisome proliferator-activated receptor-γ (PPARγ)...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Katsouri, Loukia, Lim, Yau M., Blondrath, Katrin, Eleftheriadou, Ioanna, Lombardero, Laura, Birch, Amy M., Mirzaei, Nazanin, Irvine, Elaine E., Mazarakis, Nicholas D., Sastre, Magdalena
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087021/
https://ncbi.nlm.nih.gov/pubmed/27791018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606171113
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