A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity

BMP/SMAD signaling is a crucial regulator of intestinal differentiation(1–4). However, the molecular underpinnings of the BMP pathway in this context are unknown. Here, we characterize the mechanism by which BMP/SMAD signaling drives enterocyte differentiation. We establish that the transcription fa...

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Publicado en:Nat Genet
Autores principales: Chen, Lei, Toke, Natalie H., Luo, Shirley, Vasoya, Roshan P., Fullem, Robert L., Parthasarathy, Aditya, Perekatt, Ansu O., Verzi, Michael P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6650150/
https://ncbi.nlm.nih.gov/pubmed/30988513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0384-0
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