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A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity
BMP/SMAD signaling is a crucial regulator of intestinal differentiation(1–4). However, the molecular underpinnings of the BMP pathway in this context are unknown. Here, we characterize the mechanism by which BMP/SMAD signaling drives enterocyte differentiation. We establish that the transcription fa...
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| Опубликовано в: : | Nat Genet |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6650150/ https://ncbi.nlm.nih.gov/pubmed/30988513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0384-0 |
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