HNF4 Regulates Fatty Acid Oxidation and is Required for Renewal of Intestinal Stem Cells in Mice

BACKGROUND & AIMS: Functions of intestinal stem cells (ISCs) are regulated by diet and metabolic pathways. Hepatocyte nuclear factor 4 (HNF4) are transcription factors that bind fatty acids. We investigated how HNF4 transcription factors regulate metabolism and their functions in ISCs in mice. M...

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Veröffentlicht in:Gastroenterology
Hauptverfasser: Chen, Lei, Vasoya, Roshan P., Toke, Natalie H., Parthasarathy, Aditya, Luo, Shirley, Chiles, Eric, Flores, Juan, Gao, Nan, Bonder, Edward M., Su, Xiaoyang, Verzi, Michael P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062567/
https://ncbi.nlm.nih.gov/pubmed/31759926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.11.031
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