Non-conventional inhibitory CD4(+)Foxp3(−)PD-1(hi) T cells as a biomarker of immune checkpoint blockade activity

A significant proportion of cancer patients do not respond to immune checkpoint blockade. To better understand the molecular mechanisms underlying these treatments, we explored the role of CD4(+)Foxp3(−) T cells expressing PD-1 (4PD1(hi)) and observed that 4PD1(hi) accumulate intratumorally as a fun...

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Bibliografiska uppgifter
I publikationen:Cancer Cell
Huvudupphovsmän: Zappasodi, Roberta, Budhu, Sadna, Hellmann, Matthew D., Postow, Michael A., Senbabaoglu, Yasin, Manne, Sasikanth, Gasmi, Billel, Liu, Cailian, Zhong, Hong, Li, Yanyun, Huang, Alexander C., Hirschhorn-Cymerman, Daniel, Panageas, Katherine S., Wherry, E. John, Merghoub, Taha, Wolchok, Jedd D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6648657/
https://ncbi.nlm.nih.gov/pubmed/29894689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.05.009
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