The extruded non-template strand determines the architecture of R-loops

Three-stranded R-loop structures have been associated with genomic instability phenotypes. What underlies their wide-ranging effects on genome stability remains poorly understood. Here we combined biochemical and atomic force microscopy approaches with single molecule R-loop footprinting to demonstr...

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Udgivet i:Nucleic Acids Res
Main Authors: Carrasco-Salas, Yeraldinne, Malapert, Amélie, Sulthana, Shaheen, Molcrette, Bastien, Chazot-Franguiadakis, Léa, Bernard, Pascal, Chédin, Frédéric, Faivre-Moskalenko, Cendrine, Vanoosthuyse, Vincent
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6648340/
https://ncbi.nlm.nih.gov/pubmed/31066439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz341
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