Five Years of Successful Inducible Transgene Expression Following Locoregional Adeno-Associated Virus Delivery in Nonhuman Primates with No Detectable Immunity

Anti-transgene immune responses elicited after intramuscular (i.m.) delivery of recombinant adeno-associated virus (rAAV) have been shown to hamper long-term transgene expression in large-animal models of rAAV-mediated gene transfer. To overcome this hurdle, an alternative mode of delivery of rAAV v...

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Veröffentlicht in:Hum Gene Ther
Hauptverfasser: Guilbaud, Mickaël, Devaux, Marie, Couzinié, Celia, Le Duff, Johanne, Toromanoff, Alice, Vandamme, Céline, Jaulin, Nicolas, Gernoux, Gwladys, Larcher, Thibaut, Moullier, Philippe, Le Guiner, Caroline, Adjali, Oumeya
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc., publishers 2019
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6648187/
https://ncbi.nlm.nih.gov/pubmed/30808235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2018.234
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