AAV8 locoregional delivery induces long-term expression of an immunogenic transgene in macaques despite persisting local inflammation

Adeno-associated virus (AAV) vectors are considered efficient vectors for gene transfer, as illustrated by recent successful clinical trials targeting retinal or neurodegenerative disorders. However, limitations as host immune responses to AAV capsid or transduction of limited regions must still be...

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Bibliografiset tiedot
Julkaisussa:Mol Ther Methods Clin Dev
Päätekijät: Gernoux, Gwladys, Guilbaud, Mickaël, Devaux, Marie, Journou, Malo, Pichard, Virginie, Jaulin, Nicolas, Léger, Adrien, Le Duff, Johanne, Deschamps, Jack-Yves, Le Guiner, Caroline, Moullier, Philippe, Cherel, Yan, Adjali, Oumeya
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Gene & Cell Therapy 2021
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7907542/
https://ncbi.nlm.nih.gov/pubmed/33718516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2021.02.003
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