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Cysteine-rich granulin-3 rapidly promotes amyloid-β fibrils in both redox states

Granulins (GRNs 1–7) are cysteine-rich proteolytic products of progranulin (PGRN) that have recently been implicated in neurodegenerative diseases including frontotemporal dementia (FTD) and Alzheimer’s disease (AD). Their precise mechanism in these pathologies remains uncertain, but both inflammato...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochem J
Prif Awduron: Bhopatkar, Anukool A., Ghag, Gaurav, Wolf, Lauren M., Dean, Dexter N., Moss, Melissa A., Rangachari, Vijayaraghavan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6647844/
https://ncbi.nlm.nih.gov/pubmed/30782973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20180916
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