Granulins modulate liquid–liquid phase separation and aggregation of the prion-like C-terminal domain of the neurodegeneration-associated protein TDP-43

TAR DNA-binding protein 43 (TDP-43) has emerged as a key player in many neurodegenerative pathologies, including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Hallmarks of both FTLD and ALS are the toxic cytoplasmic inclusions of the prion-like C-terminal fragment...

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Udgivet i:J Biol Chem
Main Authors: Bhopatkar, Anukool A., Uversky, Vladimir N., Rangachari, Vijayaraghavan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039568/
https://ncbi.nlm.nih.gov/pubmed/31911437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011501
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