Granulins modulate liquid–liquid phase separation and aggregation of the prion-like C-terminal domain of the neurodegeneration-associated protein TDP-43

TAR DNA-binding protein 43 (TDP-43) has emerged as a key player in many neurodegenerative pathologies, including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Hallmarks of both FTLD and ALS are the toxic cytoplasmic inclusions of the prion-like C-terminal fragment...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Biol Chem
Hlavní autoři: Bhopatkar, Anukool A., Uversky, Vladimir N., Rangachari, Vijayaraghavan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Molecular Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039568/
https://ncbi.nlm.nih.gov/pubmed/31911437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011501
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky