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The role of liquid–liquid phase separation in aggregation of the TDP-43 low-complexity domain
Pathological aggregation of the transactive response DNA-binding protein of 43 kDa (TDP-43) is associated with several neurodegenerative disorders, including ALS, frontotemporal dementia, chronic traumatic encephalopathy, and Alzheimer's disease. TDP-43 aggregation appears to be largely driven...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6484124/ https://ncbi.nlm.nih.gov/pubmed/30814253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007222 |
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