Fully reduced granulin-B is intrinsically disordered and displays concentration-dependent dynamics

Granulins (Grns) are a family of small, cysteine-rich proteins that are generated upon proteolytic cleavage of their precursor, progranulin (Pgrn). All seven Grns (A–G) contain 12 conserved cysteines that form 6 intramolecular disulfide bonds, rendering this family of proteins unique. Grns are known...

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Detalhes bibliográficos
Publicado no:Protein Eng Des Sel
Main Authors: Ghag, Gaurav, Wolf, Lauren M., Reed, Randi G., Van Der Munnik, Nicholas P., Mundoma, Claudius, Moss, Melissa A., Rangachari, Vijayaraghavan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830411/
https://ncbi.nlm.nih.gov/pubmed/26957645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzw005
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