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Neuronal Expression of UBQLN2(P497H) Exacerbates TDP-43 Pathology in TDP-43(G348C) Mice through Interaction with Ubiquitin
Mutations in the gene encoding ubiquilin-2 (UBQLN2) are linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). UBQLN2 plays a central role in ubiquitin proteasome system (UPS) and UBQLN2 up-regulation exacerbates TDP-43 cytoplasmic aggregates. To analyze interaction between...
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| Publicado en: | Mol Neurobiol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Springer US
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6647471/ https://ncbi.nlm.nih.gov/pubmed/30377984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-1411-3 |
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