Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology

BACKGROUND: The brain predominantly expressed RING finger protein, Znf179, is known to be important for embryonic neuronal differentiation during brain development. Downregulation of Znf179 has been observed in motor neurons of adult mouse models for amyotrophic lateral sclerosis (ALS), yet the mole...

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Bibliographic Details
Published in:J Biomed Sci
Main Authors: Lee, Yi-Chao, Huang, Wan-Chen, Lin, Jiann-Her, Kao, Tzu-Jen, Lin, Hui-Ching, Lee, Kuen-Haur, Lin, Hsin-Chuan, Shen, Che-Kun James, Chang, Wen-Chang, Huang, Chi-Chen
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6223059/
https://ncbi.nlm.nih.gov/pubmed/30404641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-018-0479-4
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