Znf179 induces differentiation and growth arrest of human primary glioblastoma multiforme in a p53-dependent cell cycle pathway

Malignant glioblastoma multiforme (GBM) is an aggressive brain tumor with strong local invasive growth and a poor prognosis. One probable way to manipulate GBM cells toward a less invasive status is to reprogram the most malignant GBM cells to a more differentiated and less oncogenic phenotype. Here...

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Pubblicato in:Sci Rep
Autori principali: Lee, Kuen-Haur, Chen, Chi-Long, Lee, Yi-Chao, Kao, Tzu-Jen, Chen, Kai-Yun, Fang, Chih-Yeu, Chang, Wen-Chang, Chiang, Yung-Hsaio, Huang, Chi-Chen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500472/
https://ncbi.nlm.nih.gov/pubmed/28684796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05305-0
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