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An oligo-His-tag of a targeting module does not influence its biodistribution and the retargeting capabilities of UniCAR T cells

Recently, we established the controllable modular UniCAR platform technology to advance the efficacy and safety of CAR T cell therapy. The UniCAR system is composed of (i) target modules (TMs) and (ii) UniCAR armed T cells. TMs are bispecific molecules that are able to bind to the tumor cell surface...

詳細記述

保存先:
書誌詳細
出版年:Sci Rep
主要な著者: Jureczek, Justyna, Bergmann, Ralf, Berndt, Nicole, Koristka, Stefanie, Kegler, Alexandra, Puentes-Cala, Edinson, Soto, Javier Andrés, Arndt, Claudia, Bachmann, Michael, Feldmann, Anja
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6646371/
https://ncbi.nlm.nih.gov/pubmed/31332252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47044-4
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