Highly Efficient Targeting of EGFR-Expressing Tumor Cells with UniCAR T Cells via Target Modules Based on Cetuximab(®)

INTRODUCTION: Since epithelial growth factor receptor (EGFR) overexpression is linked to a variety of malignancies, it is an attractive target for immune therapy including chimeric antigen receptor (CAR)-engineered T cells. Unfortunately, CAR T cell therapy harbors the risk of severe, even life-thre...

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Detalles Bibliográficos
Publicado en:Onco Targets Ther
Main Authors: Jureczek, Justyna, Feldmann, Anja, Bergmann, Ralf, Arndt, Claudia, Berndt, Nicole, Koristka, Stefanie, Loureiro, Liliana Rodrigues, Mitwasi, Nicola, Hoffmann, Anja, Kegler, Alexandra, Bartsch, Tabea, Bachmann, Michael
Formato: Artigo
Idioma:Inglês
Publicado: Dove 2020
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7297505/
https://ncbi.nlm.nih.gov/pubmed/32606767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S245169
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