T cells engrafted with a UniCAR 28/z outperform UniCAR BB/z-transduced T cells in the face of regulatory T cell-mediated immunosuppression

Adoptive transfer of chimeric antigen receptor (CAR)-equipped T cells have demonstrated astonishing clinical efficacy in hematological malignancies recently culminating in the approval of two CAR T cell products. Despite this tremendous success, CAR T cell approaches have still achieved only moderat...

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Publicat a:Oncoimmunology
Autors principals: Kegler, Alexandra, Koristka, Stefanie, Bergmann, Ralf, Berndt, Nicole, Arndt, Claudia, Feldmann, Anja, Hoffmann, Anja, Bornhäuser, Martin, Schmitz, Marc, Bachmann, Michael P.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2019
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6685520/
https://ncbi.nlm.nih.gov/pubmed/31428518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1621676
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