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Negative Cooperative Binding of Thymidine, Ordered Substrate Binding, and Product Release of Human Mitochondrial Thymidine Kinase 2 Explain Its Complex Kinetic Properties and Physiological Functions
[Image: see text] Mitochondrial thymidine kinase 2 (TK2) catalyzes the phosphorylation of thymidine (dT) and deoxycytidine (dC) and is essential for mitochondrial function in post-mitotic tissues. The phosphorylation of dT shows negative cooperativity, but the phosphorylation of dC follows classical...
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| Veröffentlicht in: | ACS Omega |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical Society
2018
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6644362/ https://ncbi.nlm.nih.gov/pubmed/31459030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b01376 |
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