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Nonpolar Nucleoside Mimics as Active Substrates for Human Thymidine Kinases
We describe the use of nonpolar nucleoside analogs of systematically varied size and shape to probe the mechanisms by which the two human thymidine kinases (TK1 and TK2) recognize and phosphorylate their substrate, thymidine. Comparison of polar thymidine with a nonpolar isostere, 2,4-difluorotoluen...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2891540/ https://ncbi.nlm.nih.gov/pubmed/20560637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja808244t |
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