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Varied Molecular Interactions at the Active Sites of Several DNA Polymerases: Nonpolar Nucleoside Isosteres as Probes

We describe a survey of protein–DNA interactions with seven different DNA polymerases and reverse transcriptases, carried out with nonpolar nucleoside isosteres F (a thymidine analog) and Z and Q (deoxyadenosine analogues). Previous results have shown that Z and F can be efficiently replicated oppos...

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Main Authors: Morales, Juan C., Kool, Eric T.
格式: Artigo
語言:Inglês
出版: 2000
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946118/
https://ncbi.nlm.nih.gov/pubmed/20882113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja993464+
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