Probing the interaction of archaeal DNA polymerases with deaminated bases using X-ray crystallography and non-hydrogen bonding isosteric base analogues

Archaeal family-B DNA polymerases stall replication on encountering the pro-mutagenic bases uracil and hypoxanthine. This publication describes an X-ray crystal structure of Thermococcus gorgonarius polymerase in complex with a DNA containing hypoxanthine in the single-stranded region of the templat...

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Bibliografiske detaljer
Main Authors: Killelea, Tom, Ghosh, Samantak, Tan, Samuel S., Heslop, Pauline, Firbank, Susan, Kool, Eric T., Connolly, Bernard A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901926/
https://ncbi.nlm.nih.gov/pubmed/20527806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100421r
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