Wee1 Kinase Inhibitor AZD1775 Radiosensitizes Hepatocellular Carcinoma Irrespective of TP53 Mutational Status through the Induction of Replication Stress

PURPOSE: Wee1 kinase inhibitors are effective radiosensitizers in cells lacking a G1 checkpoint. In this study we examined the potential effect of Wee1 kinase inhibition on inducing replication stress in hepatocellular carcinoma (HCC). METHODS: Five independent datasets from the Oncomine Database co...

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Detalhes bibliográficos
Publicado no:Int J Radiat Oncol Biol Phys
Main Authors: Cuneo, Kyle C., Morgan, Meredith A., Davis, Mary A., Parcels, Leslie A., Parcels, Joshua, Karnak, David, Liu, Na, Maybaum, Jon, Lawrence, Theodore S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6644066/
https://ncbi.nlm.nih.gov/pubmed/26975930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2016.01.028
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