A small molecule targeting mutagenic translesion synthesis improves chemotherapy

Intrinsic and acquired drug resistance and induction of secondary malignancies limit successful chemotherapy. Because mutagenic translesion synthesis (TLS) contributes to chemoresistance as well as treatment-induced mutations, targeting TLS is an attractive avenue for improving chemotherapeutics. Ho...

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Udgivet i:Cell
Main Authors: Wojtaszek, Jessica L., Chatterjee, Nimrat, Najeeb, Javaria, Ramos, Azucena, Lee, Minhee, Bian, Ke, Xue, Jenny Y., Fenton, Benjamin A., Park, Hyeri, Li, Deyu, Hemann, Michael T., Hong, Jiyong, Walker, Graham C., Zhou, Pei
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6644000/
https://ncbi.nlm.nih.gov/pubmed/31178121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.05.028
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