Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns

Genomics has provided a detailed structural description of the cancer genome. Identifying oncogenic drivers that work primarily through dosage changes is a current challenge. Unrestrained proliferation is a critical hallmark of cancer. We constructed modular, barcoded libraries of human open reading...

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Publicado en:Cell
Main Authors: Sack, Laura Magill, Davoli, Teresa, Li, Mamie Z., Li, Yuyang, Xu, Qikai, Naxerova, Kamila, Wooten, Eric C., Bernardi, Ronald J., Martin, Timothy D., Chen, Ting, Leng, Yumei, Liang, Anthony C., Scorsone, Kathleen A., Westbrook, Thomas F., Wong, Kwok-Kin, Elledge, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6643283/
https://ncbi.nlm.nih.gov/pubmed/29576454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.02.037
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