Inhibition of NF-κB–Dependent Signaling Enhances Sensitivity and Overcomes Resistance to BET Inhibition in Uveal Melanoma

Bromodomain and extraterminal protein inhibitors (BETi) are epigenetic therapies aimed to target dysregulated gene expression in cancer cells. Despite early successes of BETi in a range of malignancies, the development of drug resistance may limit their clinical application. Here, we evaluated the m...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res
Asıl Yazarlar: Ambrosini, Grazia, Do, Catherine, Tycko, Benjamin, Realubit, Ronald B., Karan, Charles, Musi, Elgilda, Carvajal, Richard D., Chua, Vivian, Aplin, Andrew E., Schwartz, Gary K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6643281/
https://ncbi.nlm.nih.gov/pubmed/30885979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-3177
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