Impact of Combined mTOR and MEK Inhibition in Uveal Melanoma Is Driven by Tumor Genotype

Uveal melanomas possess activation of the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/AKT/mammalian Target of Rapamycin (mTOR) pathways. MAPK activation occurs via somatic mutations in the heterotrimeric G protein subunits GNAQ and GNA11 for over 70% of tumors and le...

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Main Authors: Ho, Alan L., Musi, Elgilda, Ambrosini, Grazia, Nair, Jayasree S., Deraje Vasudeva, Shyamprasad, de Stanchina, Elisa, Schwartz, Gary K.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393714/
https://ncbi.nlm.nih.gov/pubmed/22808163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040439
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