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Engineered Aminoacyl-tRNA Synthetases with Improved Selectivity toward Noncanonical Amino Acids
A wide range of noncanonical amino acids (ncAAs) can be incorporated into proteins in living cells by using engineered aminoacyl-tRNA synthetase/tRNA pairs. However, most engineered tRNA synthetases are polyspecific; that is, they can recognize multiple rather than one ncAA. Polyspecificity of engin...
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| Izdano u: | ACS Chem Biol |
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| Glavni autori: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6642615/ https://ncbi.nlm.nih.gov/pubmed/30933556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00088 |
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