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Engineered Aminoacyl-tRNA Synthetases with Improved Selectivity toward Noncanonical Amino Acids

A wide range of noncanonical amino acids (ncAAs) can be incorporated into proteins in living cells by using engineered aminoacyl-tRNA synthetase/tRNA pairs. However, most engineered tRNA synthetases are polyspecific; that is, they can recognize multiple rather than one ncAA. Polyspecificity of engin...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Kwok, Hui Si, Vargas-Rodriguez, Oscar, Melnikov, Sergey V., Söll, Dieter
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642615/
https://ncbi.nlm.nih.gov/pubmed/30933556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00088
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