Alternative splicing regulates stochastic NLRP3 activity

Leucine-rich repeat (LRR) domains are evolutionarily conserved in proteins that function in development and immunity. Here we report strict exonic modularity of LRR domains of several human gene families, which is a precondition for alternative splicing (AS). We provide evidence for AS of LRR domain...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Hoss, Florian, Mueller, James L., Rojas Ringeling, Francisca, Rodriguez-Alcazar, Juan F., Brinkschulte, Rebecca, Seifert, Gerald, Stahl, Rainer, Broderick, Lori, Putnam, Chris D., Kolodner, Richard D., Canzar, Stefan, Geyer, Matthias, Hoffman, Hal M., Latz, Eicke
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642158/
https://ncbi.nlm.nih.gov/pubmed/31324763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11076-1
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