NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

NLRP3 is a cytosolic pattern recognition receptor that senses microbes and endogenous danger signals. Upon activation, NLRP3 forms an inflammasome with the adapter ASC, resulting in caspase-1 activation, release of proinflammatory cytokines and cell death. How NLRP3 activation is regulated by transc...

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Udgivet i:J Exp Med
Main Authors: Stutz, Andrea, Kolbe, Carl-Christian, Stahl, Rainer, Horvath, Gabor L., Franklin, Bernardo S., van Ray, Olivia, Brinkschulte, Rebecca, Geyer, Matthias, Meissner, Felix, Latz, Eicke
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460996/
https://ncbi.nlm.nih.gov/pubmed/28465465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160933
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