Membrane fusogenic lysine type lipid assemblies possess enhanced NLRP3 inflammasome activation potency

Lysine (K) type cationic lipid with a propyl spacer and ditetradecyl hydrophobic moieties composing liposomes, K3C14, previously studied for gene delivery, were reported to activate the NLRP3 inflammasomes in human macrophages via the conventional phagolysosomal pathway. In this study, K3C16, a prop...

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Библиографические подробности
Опубликовано в: :Biochem Biophys Rep
Главные авторы: He, Jieyan, Li, Tianshu, Próchnicki, Tomasz, Horvath, Gabor, Latz, Eicke, Takeoka, Shinji
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2019
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462779/
https://ncbi.nlm.nih.gov/pubmed/31011633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2019.100623
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