Membrane fusogenic lysine type lipid assemblies possess enhanced NLRP3 inflammasome activation potency

Lysine (K) type cationic lipid with a propyl spacer and ditetradecyl hydrophobic moieties composing liposomes, K3C14, previously studied for gene delivery, were reported to activate the NLRP3 inflammasomes in human macrophages via the conventional phagolysosomal pathway. In this study, K3C16, a prop...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biochem Biophys Rep
Main Authors: He, Jieyan, Li, Tianshu, Próchnicki, Tomasz, Horvath, Gabor, Latz, Eicke, Takeoka, Shinji
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462779/
https://ncbi.nlm.nih.gov/pubmed/31011633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2019.100623
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