Molecular retargeting of antibodies converts immune defense against oncolytic viruses into cancer immunotherapy

Virus-neutralizing antibodies are a severe obstacle in oncolytic virotherapy. Here, we present a strategy to convert this unfavorable immune response into an anticancer immunotherapy via molecular retargeting. Application of a bifunctional adapter harboring a tumor-specific ligand and the adenovirus...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Niemann, Julia, Woller, Norman, Brooks, Jennifer, Fleischmann-Mundt, Bettina, Martin, Nikolas T., Kloos, Arnold, Knocke, Sarah, Ernst, Amanda M., Manns, Michael P., Kubicka, Stefan, Wirth, Thomas C., Gerardy-Schahn, Rita, Kühnel, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642145/
https://ncbi.nlm.nih.gov/pubmed/31324774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11137-5
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